zonula adherens การใช้

• Adherens junctions, also called zonula adherens, are multiprotein complexes formed by proteins of the catenin and cadherin families.
• The zonula occludens and zonula adherens form a continuous belt around the cell that provides a barrier to paracellular transport and are thought to be important in cell-cell communication.
• The first identified function of PLEKHA7 was is to contribute to integrity and stability of the zonula adherens junctions by linking the E-cadherin / p120 complex to the minus ends of microtubules ( MTs ) through Nezha ( CAMSAP3 ).
• In 2015, researchers discovered that PLEKHA7 recruits the so-called microprocessor complex ( association of Drosha and DGCR8 proteins ) to a growth-inhibiting site ( apical zonula adherens ) in epithelial cells instead of sites at basolateral areas of cell cell contact containing tyrosine-phosphorylated Src.